Yes, and possibly no... it will depend on which one you buy and how it gets programed.
I did the Sync 2 to Sync 3 on a 2013 and 2018 Fusions, and all the buttons still worked... but I did not program it. Dan did (person who does the programing)
If you are on the F150 forums, you can ask and get a response from someone there that has done it.
On another note, if all that is not it and you have to replace a LOT of things, Card is over 100, APIM is 100-200. Might want to look into moving it to Sync 3
This will guild you , yes it's for the fusions, but it's the same hardware.
car-part.com to find used Sync 3 parts
There are a few things that it could be
Nav card has gone defective... see if you can borrow one to test (dealers should be able to assist)
Card slot could be defective
master reset can also be done by holding the power and seek forward buttons while the sound is on.
Then go through the menus (you will hear the test at the start and can stop it right away)
If it does not allow for that, then the ACIM might have gone bad.
2013 F350 with a 8” touch screen the Nav System quit working. Says insert SD card did that did not fix it. Everybody says to do a hard reset but I go to the settings button and there is no drop-down menu coming up with it at this time so I can’t do nothing with .Any suggestions